Fadrozole hydrochloride
$300.00
CAS No.: 102676-31-3
Catalog No.: 193326
Purity: 95%
MF: C14H14ClN3
MW: 259.74
Storage: 2-8 degree Celsius
SMILES: Cl.C=1N=CN2C1CCCC2C2=CC=C(C=C2)C#N
Catalog No.: 193326
Purity: 95%
MF: C14H14ClN3
MW: 259.74
Storage: 2-8 degree Celsius
SMILES: Cl.C=1N=CN2C1CCCC2C2=CC=C(C=C2)C#N
Fadrozole hydrochloride; 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzene-1-carbonitrile hydrochloride; CAS No.: 102676-31-3; Fadrozole hydrochloride. PROPERTIES: Fadrozole hydrochloride is a crystalline solid with the molecular formula C18H18Cl2N4O2S. It displays good solubility in water and polar organic solvents. The compound is stable under ambient conditions but should be stored below 30 C in a tightly closed container to prevent moisture absorption. Safety measures include avoiding contact with skin and eyes, using appropriate respiratory protection when handling large quantities, and maintaining a well-ventilated environment. With a molecular weight of approximately 461.31 g/mol, it has moderate bioavailability and demonstrates moderate protein binding in biological systems. The compound exhibits a pKa around 3.5, making it suitable for formulation in various pharmaceutical dosage forms. APPLICATIONS: Fadrozole hydrochloride primarily functions as an aromatase inhibitor in oncology research, particularly in studying hormone-sensitive breast cancer models. It is employed in vitro to investigate estrogen-dependent cellular processes and in vivo for evaluating antitumor efficacy in xenograft models. In clinical settings, it serves as a research tool to understand resistance mechanisms against aromatase inhibitors. Additionally, it is used in combination studies to enhance the effectiveness of other chemotherapeutic agents. As described in "Steroid receptor-targeted therapies: current knowledge and future directions," Fadrozole hydrochloride contributes significantly to the development of novel treatment strategies for hormone-related cancers.
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