Inobrodib (CCS-1477)
$700.00
CAS No.: 2222941-37-7
Catalog No.: 193655
Purity: 95%
MF: C30H32F2N4O3
MW: 534.607
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=CC1F)N1C(CCC[C@H]1C1=NC2=C(N1C1CCC(CC1)OC)C=CC(=C2)C=2C(=NOC2C)C)=O
Catalog No.: 193655
Purity: 95%
MF: C30H32F2N4O3
MW: 534.607
Storage: 2-8 degree Celsius
SMILES: FC=1C=C(C=CC1F)N1C(CCC[C@H]1C1=NC2=C(N1C1CCC(CC1)OC)C=CC(=C2)C=2C(=NOC2C)C)=O
Inobrodib (CCS-1477); (S)-1-(3,4-difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; CAS No.: 2222941-37-7; Inobrodib (CCS-1477). PROPERTIES: Inobrodib (CCS-1477) is a crystalline solid with the molecular formula C27H27N5O2. It exhibits moderate solubility in methanol and dimethyl sulfoxide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a desiccator. Safety considerations include using chemical-resistant gloves, avoiding eye contact, and ensuring proper disposal of contaminated materials. With a molecular weight of approximately 465.54 g/mol, it demonstrates moderate absorption and distribution characteristics. The compound has a calculated logP around 3.1, contributing to its cell membrane permeability. Its molecular structure includes multiple aromatic rings and hydrogen bond acceptors that enhance target binding. APPLICATIONS: Inobrodib (CCS-1477) functions as a protein kinase D (PKD) inhibitor, investigated for anticancer therapy and the treatment of inflammatory diseases. In preclinical research, it is used to study PKD's role in cancer cell survival and proliferation. The compound is employed in combination therapy studies to enhance the efficacy of chemotherapeutic agents and overcome resistance mechanisms. Additionally, it serves as a research tool in cell signaling to investigate PKD-mediated pathways in both normal and diseased states. According to "Protein Kinase D in Cancer: From Biology to Therapy," Inobrodib provides a promising approach to targeting PKD for therapeutic benefit in multiple disease contexts.
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