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AZD3514; 1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone; CAS No.: 1240299-33-5; 1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone, a trifluoromethylated triazolopyridazine, exemplifies our building blocks for CNS-penetrant kinase inhibitors. The trifluoromethyl group enhances BBB penetration. ChemShuttle s small molecule synthesis employs flow chemistry for exothermic triazole formation.