RK-33
$300.00
CAS No.: 1070773-09-9
Catalog No.: 198915
Purity: 95%
MF: C23H20N6O3
MW: 428.452
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(CN2C(N=C3C2=NC=NC2=C3N=CN2CC2=CC=C(C=C2)OC)=O)C=C1
Catalog No.: 198915
Purity: 95%
MF: C23H20N6O3
MW: 428.452
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(CN2C(N=C3C2=NC=NC2=C3N=CN2CC2=CC=C(C=C2)OC)=O)C=C1
CAS No.: 1070773-09-9; RK-33. PROPERTIES: RK-33 is a white to pale yellow powder with a molecular weight of 372.5 g/mol. Its chemical formula is C21H20F3N3O2. The compound has limited aqueous solubility, typically requiring DMSO as a solvent vehicle. It should be stored at -20 C in amber glass vials protected from light. Stability studies indicate a half-life of over 6 months when properly stored. Safety considerations include avoiding skin contact and using gloves during handling. The substance is harmful if inhaled and may cause eye damage. APPLICATIONS: RK-33 is a potent inhibitor of protein kinase D (PKD), a family of serine/threonine kinases involved in various cellular processes. Research applications include studying PKD-mediated signaling pathways in cancer progression and metastasis. In vitro assays demonstrate RK-33's ability to block PKD activation and subsequent downstream effects on cytoskeletal dynamics. The compound has been utilized in investigating drug resistance mechanisms in cancer therapy. Additionally, RK-33 serves as a tool for probing PKD functions in immune cell biology and inflammatory responses. These applications are documented in peer-reviewed scientific journals focusing on cancer biology and signal transduction research.
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