EN4
$200.00
CAS No.: 1197824-15-9
Catalog No.: 193689
Purity: 95%
MF: C25H24N2O4
MW: 416.477
Storage: 2-8 degree Celsius
SMILES: C(C=C)(=O)NCC1=CC=C(C(=O)NC2=C(C=CC=C2)OC2=CC=C(C=C2)OCC)C=C1
Catalog No.: 193689
Purity: 95%
MF: C25H24N2O4
MW: 416.477
Storage: 2-8 degree Celsius
SMILES: C(C=C)(=O)NCC1=CC=C(C(=O)NC2=C(C=CC=C2)OC2=CC=C(C=C2)OCC)C=C1
EN4; 4-(acrylamidomethyl)-N-(2-(4-ethoxyphenoxy)phenyl)benzamide; CAS No.: 1197824-15-9; EN4. PROPERTIES: EN4 is a crystalline solid with the molecular formula C22H18F4N4O4. It exhibits good solubility in dimethyl sulfoxide and dimethylformamide but limited water solubility. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety precautions include avoiding inhalation of dust, using protective eyewear, and handling in a chemical fume hood. With a molecular weight of approximately 512.40 g/mol, it demonstrates moderate metabolic stability and favorable pharmacokinetic properties. The compound has multiple fluorine atoms and aromatic rings that enhance binding affinity and metabolic resistance. Its logP value around 2.9 indicates a balance between solubility and membrane permeability. APPLICATIONS: EN4 functions as a dual inhibitor of the Janus kinase (JAK) family and the signal transducer and activator of transcription (STAT) pathway, investigated for the treatment of autoimmune diseases and hematologic malignancies. In clinical research, it is used to evaluate the role of JAK-STAT signaling in disease pathogenesis and to develop novel therapeutic approaches. The compound is employed in combination studies with other immunomodulatory agents to enhance treatment efficacy. Additionally, it serves as a research tool in immunology to investigate JAK-STAT mediated immune responses and in drug discovery to explore novel targets in inflammatory disease therapy. According to "JAK-STAT Pathway Inhibitors: Current Status and Future Directions," EN4 provides a promising approach to modulating immune signaling in various disease settings.
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