Desmorpholinyl Navitoclax-NH-Me
$500.00
CAS No.: 2365172-82-1
Catalog No.: 195297
Purity: 95%
MF: C44H51ClF3N5O5S3
MW: 918.57
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C1=C(CC(CC1)(C)C)CN1CCN(CC1)C1=CC=C(C(=O)NS(=O)(=O)C2=CC(=C(C=C2)N[C@@H](CSC2=CC=CC=C2)CCNC)S(=O)(=O)C(F)(F)F)C=C1
Catalog No.: 195297
Purity: 95%
MF: C44H51ClF3N5O5S3
MW: 918.57
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C1=C(CC(CC1)(C)C)CN1CCN(CC1)C1=CC=C(C(=O)NS(=O)(=O)C2=CC(=C(C=C2)N[C@@H](CSC2=CC=CC=C2)CCNC)S(=O)(=O)C(F)(F)F)C=C1
Desmorpholinyl Navitoclax-NH-Me; (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(methylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide; CAS No.: 2365172-82-1; Desmorpholinyl Navitoclax-NH-Me. PROPERTIES: Desmorpholinyl Navitoclax-NH-Me is a small molecule inhibitor appearing as a white to pale yellow solid. This compound has a molecular weight of approximately 400-500 g/mol. It is moderately soluble in DMSO and dimethylformamide but has limited water solubility. Desmorpholinyl Navitoclax-NH-Me should be stored at -20 C in a tightly sealed container to maintain stability. It is sensitive to moisture and light. Safety precautions include avoiding skin and eye contact as it may cause irritation. APPLICATIONS: Desmorpholinyl Navitoclax-NH-Me is used in cancer research as a potent inhibitor of BCL-2 family proteins. It facilitates the study of apoptosis regulation in various cancer cell lines. In pharmacology, it serves as a tool to investigate the mechanisms of chemoresistance. In preclinical models, Desmorpholinyl Navitoclax-NH-Me demonstrates antiproliferative effects and is studied for potential therapeutic applications. These applications are reported in oncology research papers and apoptosis signaling literature.
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