NH2-PEG6-Boc
$200.00
CAS No.: 1286281-32-0
Catalog No.: 198472
Purity: 95%
MF: C19H39NO8
MW: 409.52
Storage: 2-8 degree Celsius
SMILES: NCCOCCOCCOCCOCCOCCOCCC(=O)OC(C)(C)C
Catalog No.: 198472
Purity: 95%
MF: C19H39NO8
MW: 409.52
Storage: 2-8 degree Celsius
SMILES: NCCOCCOCCOCCOCCOCCOCCC(=O)OC(C)(C)C
CAS No.: 1286281-32-0; NH2-PEG6-Boc. PROPERTIES: NH2-PEG6-Boc is an amine-terminated PEG derivative with molecular formula C18H39N2O7 and molecular weight 401.51 g/mol. It typically exists as a colorless viscous liquid with good solubility in water and common organic solvents. The compound is sensitive to acid and should be stored at room temperature in a tightly sealed container. Safety considerations include potential for causing eye irritation, requiring safety goggles during handling. APPLICATIONS: In bioconjugation chemistry, NH2-PEG6-Boc serves as a PEGylation agent with a protected amine group. The Boc group protects the terminal amine during synthesis and can be removed under acidic conditions to release the amine for further reaction. This allows controlled introduction of PEG chains to biomolecules via amide bond formation or other amine-reactive chemistries. In pharmaceutical research, the compound is used to develop PEGylated therapeutics where the PEG chain improves solubility and reduces immunogenicity. The protected amine enables sequential modification strategies where PEGylation is followed by additional conjugation steps after Boc deprotection. In materials science, NH2-PEG6-Boc is used to functionalize surfaces or nanoparticles with PEG for improved biocompatibility, with the protected amine allowing further functionalization after deprotection. In chemical biology, the compound facilitates attachment of PEG tags to proteins or nucleic acids to study their interactions and modifications. The Boc protection strategy provides temporal control over amine availability, enabling multi-step bioconjugation processes with defined reaction sequences. (Bioconjugation protocols and materials science literature)
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