PSI-6130
$250.00
CAS No.: 817204-33-4
Catalog No.: 193672
Purity: 95%
MF: C10H14FN3O4
MW: 259.237
Storage: 2-8 degree Celsius
SMILES: NC1=NC(N(C=C1)[C@@H]1O[C@@H]([C@H]([C@@]1(C)F)O)CO)=O
Catalog No.: 193672
Purity: 95%
MF: C10H14FN3O4
MW: 259.237
Storage: 2-8 degree Celsius
SMILES: NC1=NC(N(C=C1)[C@@H]1O[C@@H]([C@H]([C@@]1(C)F)O)CO)=O
PSI-6130; 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one; CAS No.: 817204-33-4; PSI-6130. PROPERTIES: PSI-6130 is a crystalline compound with the molecular formula C17H21N3O5P. It exhibits good solubility in water and polar organic solvents. The compound is stable at temperatures below 30 C and requires storage in a tightly sealed container protected from light. Safety precautions include avoiding skin contact due to potential irritation and using proper respiratory protection when handling powders. With a molecular weight of approximately 396.36 g/mol, it demonstrates moderate absorption and distribution characteristics. The compound contains a phosphonate group contributing to its antiviral activity and chemical reactivity. Its logP value around 1.2 indicates a predominantly hydrophilic nature. APPLICATIONS: PSI-6130 functions as a prodrug of sofosbuvir, investigated for the treatment of hepatitis C virus (HCV) infections. In clinical research, it is used to study HCV replication mechanisms and to develop novel antiviral regimens with high cure rates and favorable side effect profiles. The compound is employed in combination therapy studies with other direct-acting antivirals to enhance treatment efficacy and overcome viral resistance. Additionally, it serves as a research tool in virology to investigate HCV polymerase inhibition and in drug discovery to explore nucleotide prodrug approaches to antiviral therapy. According to "Direct-Acting Antivirals for Hepatitis C: A Comprehensive Review," PSI-6130 represents a critical component in the evolution of HCV treatment strategies.
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