(R)-4-benzyl-3-phenylpiperazin-2-one
$300.00
CAS No.: 1327310-56-4
Catalog No.: 192777
Purity: 95%
MF: C17H18N2O
MW: 266.344
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)N1[C@@H](C(NCC1)=O)C1=CC=CC=C1
Catalog No.: 192777
Purity: 95%
MF: C17H18N2O
MW: 266.344
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)N1[C@@H](C(NCC1)=O)C1=CC=CC=C1
(R)-4-benzyl-3-phenylpiperazin-2-one; CAS No.: 1327310-56-4; (R)-4-benzyl-3-phenylpiperazin-2-one. PROPERTIES: This chiral piperazinone has molecular formula C19H20N2O. It appears as a white crystalline powder. The (R)-4-benzyl-3-phenylpiperazin-2-one demonstrates limited solubility in water but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 125-130 C, and it has a molecular weight of approximately 288.37 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong acids and may hydrolyze to the corresponding amine upon exposure to aqueous conditions. In case of spillage, absorb with inert material and dispose of in accordance with local regulations. APPLICATIONS: The (R)-4-benzyl-3-phenylpiperazin-2-one serves as a key intermediate in the synthesis of serotonin receptor antagonists for psychiatric disorders where the piperazinone ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The benzyl and phenyl groups enhance metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of chiral ligands for asymmetric catalysis, achieving enantiomeric excesses above 95% in certain hydrogenation reactions as described in synthetic chemistry journals. The ketone group can be further functionalized through reduction or alkylation reactions to produce various derivatives for chemical research applications.
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