(1-methylpiperazin-2-yl)methanol dihydrochloride
$250.00
CAS No.: 1312784-83-0
Catalog No.: 192776
Purity: 95%
MF: C6H16Cl2N2O
MW: 203.113
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.CN1C(CNCC1)CO
Catalog No.: 192776
Purity: 95%
MF: C6H16Cl2N2O
MW: 203.113
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.CN1C(CNCC1)CO
(1-methylpiperazin-2-yl)methanol dihydrochloride; CAS No.: 1312784-83-0; (1-methylpiperazin-2-yl)methanol dihydrochloride. PROPERTIES: This methylated piperazine methanol salt has molecular formula C6H14N2O {2HCl. It typically appears as a white crystalline powder. The (1-methylpiperazin-2-yl)methanol dihydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 180-185 C (with decomposition), and it has a molecular weight of approximately 198.10 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The dihydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The (1-methylpiperazin-2-yl)methanol dihydrochloride functions as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the piperazine ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The methanol group forms additional hydrogen bonds with receptor residues. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the hydroxyl group reacts with targeting moieties, as described in pharmaceutical sciences journals. The hydroxyl group can be further functionalized through etherification or esterification reactions to produce various derivatives for chemical research applications.
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