N4-Benzoylcytidine
$265.00
CAS No.: 13089-48-0
Catalog No.: 198204
Purity: 95%
MF: C16H17N3O6
MW: 347.327
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)(=O)NC1=NC(N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=O
Catalog No.: 198204
Purity: 95%
MF: C16H17N3O6
MW: 347.327
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)(=O)NC1=NC(N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=O
CAS No.: 13089-48-0; N4-Benzoylcytidine. PROPERTIES: N4-Benzoylcytidine is a benzoylated nucleoside with molecular formula C15H15N3O7P and molecular weight 414.27 g/mol. It typically appears as a colorless crystalline solid with limited aqueous solubility, requiring organic solvents like methanol or DMSO for dissolution. The compound is sensitive to light and should be stored at -20 C in amber glass bottles under nitrogen atmosphere. Safety precautions include handling in well-ventilated areas and using protective equipment to prevent skin and eye contact. APPLICATIONS: In nucleic acid chemistry, N4-Benzoylcytidine serves as a protected cytidine derivative used in oligonucleotide synthesis. The benzoyl group protects the N4 amino group during phosphoramidite coupling reactions and is typically removed under mild alkaline conditions post-synthesis. In molecular biology, the compound is utilized in synthesizing modified oligonucleotides for studying RNA structure and function, as well as in developing antisense therapeutics and siRNA molecules with improved stability and targeting efficiency. Additionally, the benzoyl-protected cytidine is employed in chemical biology to investigate RNA-protein interactions and to map RNA modification sites in cellular RNA populations. The compound's photostability and chemical stability make it suitable for incorporation into RNA probes used in fluorescence in situ hybridization (FISH) and other RNA detection techniques. (Oligonucleotide synthesis protocols and molecular biology research articles)
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