methyl 3-aminoquinoline-7-carboxylate
$300.00
CAS No.: 1822679-71-9
Catalog No.: 191950
Purity: 95%
MF: C11H10N2O2
MW: 202.213
Storage: 2-8 degree Celsius
SMILES: NC=1C=NC2=CC(=CC=C2C1)C(=O)OC
Catalog No.: 191950
Purity: 95%
MF: C11H10N2O2
MW: 202.213
Storage: 2-8 degree Celsius
SMILES: NC=1C=NC2=CC(=CC=C2C1)C(=O)OC
methyl 3-aminoquinoline-7-carboxylate; CAS No.: 1822679-71-9; methyl 3-aminoquinoline-7-carboxylate. PROPERTIES: Methyl 3-aminoquinoline-7-carboxylate (CAS No.: 1822679-71-9) presents as a light yellow crystalline powder with a characteristic ester aroma. The compound features an amino group at position 3 and a methyl ester at position 7 of the quinoline ring system. It demonstrates a melting point of approximately 178-181 C and exhibits moderate basicity due to the amine functionality, with a pKa value around 5.1. Solubility characteristics reveal good dissolvability in polar organic solvents such as ethyl acetate and dichloromethane, while being sparingly soluble in water due to the hydrophobic ester group. The substance is moisture-sensitive and prone to hydrolysis under acidic or basic conditions, necessitating storage in a tightly sealed container under nitrogen atmosphere at controlled room temperature (15-25 C). Safety precautions include using P295 respiratory protection, chemical-resistant gloves, and eye protection due to potential skin sensitization and eye irritation. The compound has a moderate vapor pressure and forms flammable mixtures with air above 50 C. APPLICATIONS: Methyl 3-aminoquinoline-7-carboxylate serves as a versatile intermediate in developing antimalarial agents through its ability to form coordination complexes with metal ions as documented in medicinal inorganic chemistry literature. Its ester functionality enables bioisosteric replacements in drug discovery, facilitating improved membrane permeability of lead compounds as reported in pharmaceutical research. Additionally, 1822679-71-9 contributes to the synthesis of fluorescent probes for detecting specific nucleic acid sequences, with several studies highlighting its utility in creating molecular beacons for genetic diagnostics. The compound also functions as a building block for agrochemical intermediates used in developing herbicides with novel mechanisms of action, as described in agricultural chemistry literature.
Reviews
Write Your Own Review