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Isosulfan Blue; sodium 2-((4-(diethylamino)phenyl)(4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene)methyl)benzene-1,4-disulfonate; CAS No.: 68238-36-8; Isosulfan Blue. PROPERTIES: Isosulfan Blue is a crystalline compound with the molecular formula C27H30N2O3S2. It exhibits good solubility in water and polar organic solvents. The compound is stable at room temperature but recommended storage involves protection from light and moisture in a sealed container. Safety considerations include using gloves to prevent skin staining and avoiding eye contact. With a molecular weight of approximately 498.66 g/mol, it demonstrates favorable absorption characteristics and moderate metabolic stability. The compound contains sulfonamide groups contributing to its chemical reactivity and biological activity. Its logP value around 1.9 indicates a balance between hydrophilic and lipophilic properties. APPLICATIONS: Isosulfan Blue serves as a lymphatic vessel visualization agent, investigated in surgical procedures and diagnostic imaging. In clinical research, it is used to study lymphatic system anatomy and to develop novel approaches for lymphatic mapping in cancer surgery. The compound is employed in preclinical models to evaluate its efficacy in locating sentinel lymph nodes and in combination studies with other imaging agents to enhance visualization accuracy. Additionally, it functions as a research tool in surgical oncology to investigate lymphatic drainage patterns and in drug delivery to explore targeted therapies for lymphatic diseases. According to "Lymphatic Mapping and Sentinel Node Biopsy in Cancer," Isosulfan Blue provides a valuable agent for improving the accuracy of lymphatic imaging and surgical procedures.