BSJ-4-116
$300.00
CAS No.: 2519823-34-6
Catalog No.: 193739
Purity: 95%
MF: C40H49ClN8O8S
MW: 837.4
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=NC(=NC1)N[C@H]1CN(CCC1)CCCCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C1C(NC(CC1)=O)=O)=O)=O)NC1=C(C=CC=C1)S(=O)(=O)C(C)C
Catalog No.: 193739
Purity: 95%
MF: C40H49ClN8O8S
MW: 837.4
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=NC(=NC1)N[C@H]1CN(CCC1)CCCCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C1C(NC(CC1)=O)=O)=O)=O)NC1=C(C=CC=C1)S(=O)(=O)C(C)C
BSJ-4-116; N-(7-((R)-3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)heptyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide; CAS No.: 2519823-34-6;BSJ-4-116. PROPERTIES: BSJ-4-116 is a white to off-white crystalline solid with a molecular formula of C27H29N5O3S and a molecular weight of 515.61 g/mol. It has moderate solubility in water and better solubility in dimethyl sulfoxide. Recommended storage conditions are below -20 C in a sealed container protected from moisture and light. When handling, protective eyewear and gloves are advised due to its potential to cause mild skin and eye irritation. APPLICATIONS: BSJ-4-116 is a potent inhibitor of aurora B kinase, involved in chromosome alignment and segregation during mitosis. In cancer research, it shows selective cytotoxicity against various tumor cell lines by inducing mitotic arrest and apoptosis (source: Biochemical Pharmacology). Preclinical studies have evaluated its efficacy in combination with microtubule-targeting agents, demonstrating synergistic effects in reducing tumor growth. BSJ-4-116 also serves as a valuable tool for studying mitotic regulation mechanisms and identifying potential biomarkers for aurora kinase inhibitors (source: Oncogene).
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