ethyl 4-(trifluoromethoxy)cyclohexane-1-carboxylate
$265.00
CAS No.: 1374655-72-7
Catalog No.: 195918
Purity: 95%
MF: C10H15F3O3
MW: 240.221
Storage: 2-8 degree Celsius
SMILES: FC(OC1CCC(CC1)C(=O)OCC)(F)F
Catalog No.: 195918
Purity: 95%
MF: C10H15F3O3
MW: 240.221
Storage: 2-8 degree Celsius
SMILES: FC(OC1CCC(CC1)C(=O)OCC)(F)F
ethyl 4-(trifluoromethoxy)cyclohexane-1-carboxylate; CAS No.: 1374655-72-7; ethyl 4-(trifluoromethoxy)cyclohexane-1-carboxylate. PROPERTIES: Ethyl 4-(trifluoromethoxy)cyclohexane-1-carboxylate has molecular formula C10H14F3O2, giving it a molecular weight of 230.21 g/mol. It appears as a white crystalline powder with a melting point between 75-78 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong nucleophilic attack. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 2.0 and exhibits moderate aqueous solubility. APPLICATIONS: This ethyl 4-(trifluoromethoxy)cyclohexane-1-carboxylate is extensively used in the synthesis of antimicrobial agents. Its cyclohexane-carboxylate-trifluoromethoxy structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The trifluoromethoxy group provides steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The carboxylate group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
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