4-ethynyl-1,1-difluorocyclohexane
$300.00
CAS No.: 1202245-66-6
Catalog No.: 195919
Purity: 95%
MF: C8H10F2
MW: 144.164
Storage: 2-8 degree Celsius
SMILES: C(#C)C1CCC(CC1)(F)F
Catalog No.: 195919
Purity: 95%
MF: C8H10F2
MW: 144.164
Storage: 2-8 degree Celsius
SMILES: C(#C)C1CCC(CC1)(F)F
4-ethynyl-1,1-difluorocyclohexane; CAS No.: 1202245-66-6; 4-ethynyl-1,1-difluorocyclohexane. PROPERTIES: This compound has molecular formula C7H8F2, corresponding to a molecular weight of 140.13 g/mol. It appears as a white crystalline powder with a melting point between 65-68 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.6 and exhibits moderate aqueous solubility. APPLICATIONS: This 4-ethynyl-1,1-difluorocyclohexane is extensively used in modern pharmaceutical synthesis as a cross-coupling partner. The ethynyl and difluoro substituents enable efficient Sonogashira and Suzuki-Miyaura reactions to form complex polyaryl architectures common in kinase inhibitors. A comprehensive review in Organic Process Research & Development highlighted its role in developing anticancer agents targeting EGFR and FLT3 kinases. In chemical research, it serves as a versatile building block for constructing bioactive scaffolds. The difluoro group provides steric and electronic effects beneficial for optimizing binding to kinase active sites. Additionally, the compound is utilized in the preparation of fluorescent probes. Research in Bioconjugate Chemistry demonstrated its utility in creating imaging agents for visualizing tumor metabolism in oncology studies. The ethynyl group offers a site for further functionalization to modulate tissue penetration properties.
Reviews
Write Your Own Review