ethyl 2-(2,2-dimethylpiperidin-4-yl)acetate hydrochloride
$343.00
CAS No.: 104094-97-5
Catalog No.: 192818
Purity: 95%
MF: C11H22ClNO2
MW: 235.755
Storage: 2-8 degree Celsius
SMILES: Cl.CC1(NCCC(C1)CC(=O)OCC)C
Catalog No.: 192818
Purity: 95%
MF: C11H22ClNO2
MW: 235.755
Storage: 2-8 degree Celsius
SMILES: Cl.CC1(NCCC(C1)CC(=O)OCC)C
ethyl 2-(2,2-dimethylpiperidin-4-yl)acetate hydrochloride; CAS No.: 104094-97-5; ethyl 2-(2,2-dimethylpiperidin-4-yl)acetate hydrochloride. PROPERTIES: This dimethylated piperidine acetate ester salt has molecular formula C12H22N2O2 {HCl. It appears as a white crystalline powder. The ethyl 2-(2,2-dimethylpiperidin-4-yl)acetate hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 120-125 C (with decomposition), and it has a molecular weight of approximately 246.78 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The ethyl 2-(2,2-dimethylpiperidin-4-yl)acetate hydrochloride serves as a valuable intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the piperidine ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The dimethyl groups enhance metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of agrochemicals with herbicidal activity, though this application is mentioned only for informational purposes per your request. The ester group can be further functionalized through hydrolysis or amidation reactions to produce various derivatives for chemical research applications.
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