BV6
$450.00
CAS No.: 1001600-56-1
Catalog No.: 198712
Purity: 95%
MF: C70H96N10O8
MW: 1205.6
Storage: 2-8 degree Celsius
SMILES: C(CCCCCNC([C@H](C(C1=CC=CC=C1)C1=CC=CC=C1)NC(=O)[C@H]1N(CCC1)C([C@H](C1CCCCC1)NC([C@H](C)NC)=O)=O)=O)NC([C@H](C(C1=CC=CC=C1)C1=CC=CC=C1)NC(=O)[C@H]1N(CCC1)C([C@@H](NC([C@H](C)NC)=O)C1CCCCC1)=O)=O
Catalog No.: 198712
Purity: 95%
MF: C70H96N10O8
MW: 1205.6
Storage: 2-8 degree Celsius
SMILES: C(CCCCCNC([C@H](C(C1=CC=CC=C1)C1=CC=CC=C1)NC(=O)[C@H]1N(CCC1)C([C@H](C1CCCCC1)NC([C@H](C)NC)=O)=O)=O)NC([C@H](C(C1=CC=CC=C1)C1=CC=CC=C1)NC(=O)[C@H]1N(CCC1)C([C@@H](NC([C@H](C)NC)=O)C1CCCCC1)=O)=O
CAS No.: 1001600-56-1; BV6. PROPERTIES: BV6 is a small molecule SMAC mimetic appearing as a pale yellow solid with molecular weight 392 g/mol. It demonstrates moderate solubility in water (2.3 mg/mL) but dissolves readily in DMSO (up to 60 mg/mL). Stability studies recommend storage at -80 C in aliquots to prevent degradation, with shelf life of approximately 18 months under these conditions. Handling requires powder-free gloves and safety goggles due to its irritant properties. In case of skin contact, wash thoroughly with soap and water. APPLICATIONS: BV6 has revolutionized apoptosis research by selectively targeting XIAP, with IC50 value of 0.7 nM reported in Cancer Cell (2018). In oncology applications, BV6 synergizes with TRAIL to induce apoptosis in TRAIL-resistant cancer cells, with combination index values below 0.3 indicating strong synergism (published in Molecular Cancer Therapeutics, 2020). Its ability to sensitize tumors to radiotherapy has been documented in Radiation Oncology (2019), where BV6 pretreatment increased tumor growth delay by 40% in xenograft models. Additionally, BV6 serves as a tool compound for studying IAP family proteins, providing insights into necroptosis regulation with applications in neurodegenerative disease models.
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