diethyl 2-(aminomethylene)malonate
$300.00
CAS No.: 6296-99-7
Catalog No.: WLZ1347
Purity: 95%
MF: C8H13NO4
MW: 187.195
Storage: 2-8 degree Celsius
SMILES: NC=C(C(=O)OCC)C(=O)OCC
Catalog No.: WLZ1347
Purity: 95%
MF: C8H13NO4
MW: 187.195
Storage: 2-8 degree Celsius
SMILES: NC=C(C(=O)OCC)C(=O)OCC
CAS NO.: 6296-99-7; diethyl 2-(aminomethylene)malonate. PROPERTIES: This reactive ester features two ethyl ester groups attached to a malonate framework bearing an aminomethylene group, creating a molecule with potential applications in organic synthesis and pharmaceutical research. The diethyl 2-(aminomethylene)malonate typically presents as a colorless to pale yellow liquid with moderate solubility in common organic solvents. Its molecular structure includes a Michael acceptor system that can undergo nucleophilic addition reactions. For optimal stability and to prevent undesired reactions, this compound should be stored at 2-8 degree Celsius in an amber glass bottle under an inert atmosphere. When handling, appropriate safety measures including nitrile gloves and safety goggles are essential. This compound is sensitive to moisture and may hydrolyze in aqueous environments. In case of skin contact, wash immediately with soap and water; if eye contact occurs, rinse thoroughly and seek medical evaluation. APPLICATIONS: The diethyl 2-(aminomethylene)malonate serves as a valuable building block in organic synthesis, particularly for creating -amino acid derivatives and other nitrogen-containing compounds. The aminomethylene group provides a handle for Michael addition reactions with various nucleophiles. In medicinal chemistry, this compound functions as an intermediate for developing -lactam antibiotics and other heterocyclic pharmaceuticals where the malonate framework contributes to ring-forming reactions. Additionally, the molecule finds utility in materials science as a monomer for creating polymers with specific optical and electronic properties. Researchers utilizing this compound can benefit from its reactive Michael system, enabling the development of diverse molecular architectures for applications ranging from drug discovery to advanced materials.
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