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8-bromo-6-chloro-2-methyl-[1,2,4]triazolo[1,5-a]pyridine
$200.00
CAS No.: 1159813-15-6
Catalog No.: 197680
Purity: 95%
MF: C7H5BrClN3
MW: 246.495
Storage: 2-8 degree Celsius
SMILES: BrC=1C=2N(C=C(C1)Cl)N=C(N2)C
Catalog No.: 197680
Purity: 95%
MF: C7H5BrClN3
MW: 246.495
Storage: 2-8 degree Celsius
SMILES: BrC=1C=2N(C=C(C1)Cl)N=C(N2)C
8-bromo-6-chloro-2-methyl-[1,2,4]triazolo[1,5-a]pyridine; CAS No.: 1159813-15-6;8-bromo-6-chloro-2-methyl-[1,2,4]triazolo[1,5-a]pyridine. PROPERTIES: 8-bromo-6-chloro-2-methyl-[1,2,4]triazolo[1,5-a]pyridine is a polyhalogenated heterocycle with a molecular weight of 257.01 g/mol. This white crystalline solid has a melting point between 125-128 C. The molecule features a triazolo[1,5-a]pyridine ring system with a bromo substituent at position 8, a chloro group at position 6, and a methyl group at position 2. It demonstrates limited solubility in common organic solvents such as ethyl acetate and methanol but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the multiple halogen substituents' potential to release toxic fumes when heated and the heterocycle's general toxicity. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of pharmaceuticals and specialty chemicals, where the halogenated triazolopyridine structure provides versatile sites for cross-coupling and nucleophilic substitution reactions. In medicinal chemistry, it has been employed in developing antiparasitic agents targeting protozoan infections and has shown utility in creating kinase inhibitors for cancer therapy. The polyhalogenated triazolopyridine structure has also been explored in materials science for developing nonlinear optical materials, leveraging the polarizable halogen atoms to enhance optical properties. These applications are supported by research published in the Journal of Medicinal Chemistry and the Journal of Materials Chemistry C.
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