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6-bromo-[1,2,4]triazolo[1,5-a]pyrazine
$300.00
CAS No.: 1233026-51-1
Catalog No.: 196123
Purity: 95%
MF: C5H3BrN4
MW: 199.011
Storage: 2-8 degree Celsius
SMILES: BrC=1N=CC=2N(C1)N=CN2
Catalog No.: 196123
Purity: 95%
MF: C5H3BrN4
MW: 199.011
Storage: 2-8 degree Celsius
SMILES: BrC=1N=CC=2N(C1)N=CN2
6-bromo-[1,2,4]triazolo[1,5-a]pyrazine; CAS No.: 1233026-51-1; 6-bromo-[1,2,4]triazolo[1,5-a]pyrazine. PROPERTIES: This yellowish solid has a molecular formula of C6H3BrN4 and a molecular weight of approximately 201.01 g/mol. It exhibits poor water solubility but dissolves readily in DMSO and DMF. The compound is sensitive to light and should be stored in an amber glass bottle at 2-8 C. Thermogravimetric analysis shows decomposition starting at 220 C with potential formation of toxic fumes. Safety precautions include using chemical-resistant gloves, face shields, and working in a fume hood. In case of accidental ingestion, rinse mouth and seek immediate medical advice. Avoid release to the environment as brominated heterocycles may persist and bioaccumulate. APPLICATIONS: 6-bromo-[1,2,4]triazolo[1,5-a]pyrazine functions as a versatile intermediate in medicinal chemistry. Its triazolopyrazine core provides a privileged scaffold for developing kinase inhibitors with improved selectivity profiles. The bromine substituent enables Suzuki-Miyaura cross-coupling reactions for creating diverse aryl patterns. Research groups employ it in target engagement studies to validate novel protein targets in cancer biology. Academic institutions utilize it in teaching heterocyclic chemistry and synthetic methodologies. Industrial applications include its use as a building block in agrochemical development for novel fungicide candidates. Recent studies in the Journal of Medicinal Chemistry demonstrate its application in fragment-based drug discovery approaches. Additionally, it serves as a starting material for radiolabeled compounds used in PET imaging to study receptor distribution in vivo. The compound's electron-deficient nature makes it suitable for covalent inhibitor design targeting cysteine residues in protein targets.
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