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2-iodothiazole; CAS No.: 3034-54-6;2-iodothiazole. PROPERTIES: 2-iodothiazole is a halogenated heterocycle with a molecular weight of 193.08 g/mol. This colorless to pale yellow liquid has a boiling point around 125-127 C at 760 mmHg. The thiazole ring features an iodine substituent at position 2. It demonstrates moderate solubility in common organic solvents such as diethyl ether and chloroform but limited water solubility. The compound is sensitive to light and should be stored in amber glass containers at temperatures below 10 C. Safety considerations include the iodine substituent's potential to cause skin and respiratory irritation and the thiazole ring's general toxicity. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of pharmaceuticals and agrochemicals, where the iodine substituent provides a versatile site for cross-coupling reactions. In medicinal chemistry, it has been employed in developing antitubercular agents and has shown utility in creating herbicides with novel modes of action targeting plant enzyme systems. The iodinated thiazole structure has also been explored in materials science for developing organic semiconductors, leveraging the heavy atom effect to enhance charge carrier mobility. These applications are supported by research published in the Journal of Organic Chemistry and Advanced Materials.