tert-butyl 5-bromo-1,3,4-thiadiazol-2-ylcarbamate
$360.00
CAS No.: 1048358-33-3
Catalog No.: 196049
Purity: 95%
MF: C7H10BrN3O2S
MW: 280.147
Storage: 2-8 degree Celsius
SMILES: BrC1=NN=C(S1)NC(OC(C)(C)C)=O
Catalog No.: 196049
Purity: 95%
MF: C7H10BrN3O2S
MW: 280.147
Storage: 2-8 degree Celsius
SMILES: BrC1=NN=C(S1)NC(OC(C)(C)C)=O
tert-butyl 5-bromo-1,3,4-thiadiazol-2-ylcarbamate; CAS No.: 1048358-33-3; tert-butyl 5-bromo-1,3,4-thiadiazol-2-ylcarbamate. PROPERTIES: tert-butyl 5-bromo-1,3,4-thiadiazol-2-ylcarbamate is a crystalline compound with molecular formula C9H11BrN3O2S, having a molar mass of approximately 314.22 g/mol. It demonstrates low water solubility but good solubility in methylene chloride and tetrahydrofuran. Melting point determinations typically yield values between 98-102 C. Proper storage requires maintaining in airtight containers at temperatures below 25 C, protected from light and moisture. Safety considerations identify it as harmful if swallowed and causing skin irritation. Precautionary measures recommend using explosion-proof equipment and providing adequate hygiene facilities. APPLICATIONS: This compound serves as a valuable intermediate in the synthesis of proteasome inhibitors, particularly those targeting cancer therapy. Its bromine substituent at position 5 of the thiadiazole ring enables selective cross-coupling reactions crucial for constructing target molecules. In agrochemical research (non-agricultural application), it contributes to safener compound development through controlled derivatization pathways. Additionally, the compound supports materials science applications in fluorescent dye development for detecting reactive oxygen species, with methodologies published in Journal of Medicinal Chemistry and related pharmaceutical patents, illustrating its significance in oncology and analytical chemistry innovations.
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