tert-butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate
$350.00
CAS No.: 1179338-62-5
Catalog No.: 196309
Purity: 95%
MF: C12H24N2O3
MW: 244.335
Storage: 2-8 degree Celsius
SMILES: NCCC1(CCN(CC1)C(=O)OC(C)(C)C)O
Catalog No.: 196309
Purity: 95%
MF: C12H24N2O3
MW: 244.335
Storage: 2-8 degree Celsius
SMILES: NCCC1(CCN(CC1)C(=O)OC(C)(C)C)O
tert-butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate; CAS No.: 1179338-62-5; tert-butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate. PROPERTIES: This compound presents a tert-butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate structure, combining a tert-butyl ester, an aminoethyl substituent, and a hydroxypiperidine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 259.3 g/mol (C13H24N2O3). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: tert-Butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate serves as a specialized intermediate in pharmaceutical research. Its tert-butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate structure enables diverse reactivity patterns, including ester hydrolysis, nucleophilic substitution at the amino group, and hydrogen bonding interactions through the hydroxypiperidine group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The tert-butyl ester provides temporary protection for the carboxylic acid, allowing sequential synthesis steps. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the tert-butyl 4-(2-aminoethyl)-4-hydroxypiperidine-1-carboxylate scaffold for improved biological activity and target engagement.
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