tert-butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate
$300.00
CAS No.: 887588-18-3
Catalog No.: 196308
Purity: 95%
MF: C14H28N2O3
MW: 272.389
Storage: 2-8 degree Celsius
SMILES: COCCCNC1CN(CCC1)C(=O)OC(C)(C)C
Catalog No.: 196308
Purity: 95%
MF: C14H28N2O3
MW: 272.389
Storage: 2-8 degree Celsius
SMILES: COCCCNC1CN(CCC1)C(=O)OC(C)(C)C
tert-butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate; CAS No.: 887588-18-3; tert-butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate. PROPERTIES: This compound features a tert-butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate structure, combining a tert-butyl ester, a methoxypropylamino substituent, and a piperidine ring system. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 284.4 g/mol (C14H25NO3). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: tert-Butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its tert-butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate structure allows for participation in various reactions, including ester hydrolysis, nucleophilic substitution at the amino group, and hydrogen bonding interactions through the methoxy group. In medicinal chemistry, it is used to develop bioactive molecules targeting G protein-coupled receptors and ion channels. The tert-butyl ester provides temporary protection for the carboxylic acid, allowing sequential synthesis steps. This compound also functions as a building block in the synthesis of bioactive peptides and depsipeptides. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the tert-butyl 3-(3-methoxypropylamino)piperidine-1-carboxylate scaffold for improved biological activity and pharmacokinetic properties.
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