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methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate hydrochloride; CAS No.: 78348-26-2; methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate hydrochloride. PROPERTIES: Methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate hydrochloride appears as a hygroscopic white powder with a characteristic bitter taste. The salt form demonstrates enhanced water solubility compared to its free base counterpart and typical cationic profile in HPLC systems. Thermal analysis shows decomposition above 230 C with evolution of nitrogenous fumes. Storage recommendations include maintaining relative humidity below 40% and temperature below 20 C. Safety protocols emphasize avoiding dust inhalation and providing adequate ventilation as per OSHA standards for handling fine chemical powders. APPLICATIONS: Methyl 1,2,3,4-tetrahydroquinoline-2-carboxylate hydrochloride serves as an intermediate in the synthesis of beta-blockers detailed in cardiovascular pharmacology research. Its tetrahydroquinoline backbone facilitates construction of alkaloid mimetics explored in natural products chemistry. Furthermore, the compound functions as a chiral building block in asymmetric catalysis systems reported in advanced synthetic methodologies publications.