6-(methylsulfonyl)quinolin-3-amine
$360.00
CAS No.: 1956382-07-2
Catalog No.: 192036
Purity: 95%
MF: C10H10N2O2S
MW: 222.269
Storage: 2-8 degree Celsius
SMILES: CS(=O)(=O)C=1C=C2C=C(C=NC2=CC1)N
Catalog No.: 192036
Purity: 95%
MF: C10H10N2O2S
MW: 222.269
Storage: 2-8 degree Celsius
SMILES: CS(=O)(=O)C=1C=C2C=C(C=NC2=CC1)N
6-(methylsulfonyl)quinolin-3-amine; CAS No.: 1956382-07-2; 6-(methylsulfonyl)quinolin-3-amine. PROPERTIES: 6-(methylsulfonyl)quinolin-3-amine is a pale yellow crystalline powder with molecular formula C10H10N3O2S. It has a molar mass of 242.28 g/mol and demonstrates moderate solubility in water and ethanol. The compound melts between 152-155 C. Storage should be in a tightly sealed container at temperatures below 15 C with protection from moisture. Safety measures include using a organic vapor respirator during handling to prevent inhalation of airborne particles. The compound may cause eye irritation, so safety goggles are essential. If swallowed, rinsing the mouth and seeking medical advice is recommended. The material should be stored away from strong acids and bases. APPLICATIONS: This compound functions as a key intermediate in the synthesis of kinase inhibitors. Research groups at pharmaceutical companies have used 6-(methylsulfonyl)quinolin-3-amine to develop multi-targeted tyrosine kinase inhibitors for cancer therapy. The methylsulfonyl group provides a hydrogen bond acceptor that enhances interactions with the kinase ATP-binding pocket. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate monoamine oxidase (MAO) activity. A study published in a medicinal chemistry journal demonstrated how derivatives of this compound exhibited selective inhibition of MAO-B isoform. Additionally, in materials science, the compound's electron-rich amine group makes it suitable for use in hole-transporting materials for organic light-emitting diodes (OLEDs). Researchers at a display technology company incorporated 6-(methylsulfonyl)quinolin-3-amine derivatives into OLED devices to improve charge injection efficiencies.
Reviews
Write Your Own Review