2-bromo-5-fluoroquinoline
$300.00
CAS No.: 1420793-87-8
Catalog No.: 192275
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=NC2=CC=CC(=C2C=C1)F
Catalog No.: 192275
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=NC2=CC=CC(=C2C=C1)F
2-bromo-5-fluoroquinoline; CAS No.: 1420793-87-8; 2-bromo-5-fluoroquinoline. PROPERTIES: 2-bromo-5-fluoroquinoline is a crystalline substance with molecular formula C9H5BrFNN. It has a melting point of approximately 135-140 C and exhibits limited solubility in common organic solvents. The compound is light-sensitive and should be stored in amber glassware at 2-8 C. Safety precautions include wearing protective clothing due to its potential to cause skin burns and using explosion-proof ventilation due to its explosive nature when exposed to heat. APPLICATIONS: This brominated, fluorinated quinoline is used in the development of anticancer prodrugs. The bromine substituent serves as a reducible moiety that gets activated in the tumor microenvironment as reported in cancer research literature. In chemical biology, 2-bromo-5-fluoroquinoline serves as a building block for creating photoaffinity labels. According to biochemical journals, the quinoline scaffold provides a fluorescent signal while the bromine group enables photoinduced cross-linking with target proteins.
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