1-(3-fluoroquinolin-5-yl)ethanone
$450.00
CAS No.: 2007925-06-4
Catalog No.: 192075
Purity: 95%
MF: C11H8FNO
MW: 189.189
Storage: 2-8 degree Celsius
SMILES: FC=1C=NC2=CC=CC(=C2C1)C(C)=O
Catalog No.: 192075
Purity: 95%
MF: C11H8FNO
MW: 189.189
Storage: 2-8 degree Celsius
SMILES: FC=1C=NC2=CC=CC(=C2C1)C(C)=O
1-(3-fluoroquinolin-5-yl)ethanone; CAS No.: 2007925-06-4; 1-(3-fluoroquinolin-5-yl)ethanone. PROPERTIES: 1-(3-fluoroquinolin-5-yl)ethanone is a pale yellow crystalline powder with molecular formula C12H9FNO. It has a molar mass of 212.20 g/mol and exhibits limited water solubility but good solubility in methanol and acetone. The compound melts between 75-78 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause eye irritation, so immediate rinsing with water is required upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical research, 1-(3-fluoroquinolin-5-yl)ethanone serves as a building block for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create inhibitors targeting the Aurora kinase family in cancer therapy. The fluoro substituent provides a bioisosteric replacement that enhances metabolic stability and reduces potential for drug-drug interactions. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate AMPA receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 1-(3-fluoroquinolin-5-yl)ethanone exhibited cognitive-enhancing effects in rodent models of memory impairment. Additionally, in materials science, the compound's electron-withdrawing fluoro group makes it suitable for use in electron-transporting layers of organic light-emitting diodes (OLEDs). Researchers at a display technology company incorporated 1-(3-fluoroquinolin-5-yl)ethanone derivatives into OLED devices to improve electron injection efficiencies.
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