1-(3-bromoquinolin-5-yl)ethanone
$300.00
CAS No.: 2007916-77-8
Catalog No.: 192076
Purity: 95%
MF: C11H8BrNO
MW: 250.095
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NC2=CC=CC(=C2C1)C(C)=O
Catalog No.: 192076
Purity: 95%
MF: C11H8BrNO
MW: 250.095
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NC2=CC=CC(=C2C1)C(C)=O
1-(3-bromoquinolin-5-yl)ethanone; CAS No.: 2007916-77-8; 1-(3-bromoquinolin-5-yl)ethanone. PROPERTIES: 1-(3-bromoquinolin-5-yl)ethanone is a white crystalline powder with molecular formula C12H9BrNO. It has a molar mass of 267.11 g/mol and shows limited water solubility but good solubility in methanol and ethyl acetate. The compound melts between 80-83 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from light. Safety measures include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In pharmaceutical development, 1-(3-bromoquinolin-5-yl)ethanone serves as a building block for creating antibacterial agents. Research teams at antibiotic development centers have used this compound to synthesize inhibitors of bacterial type II topoisomerases. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing heat shock protein 90 (HSP90) inhibitors. A study published in a cancer research journal demonstrated how derivatives of 1-(3-bromoquinolin-5-yl)ethanone exhibited antiproliferative effects by disrupting the HSP90 chaperone function. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 1-(3-bromoquinolin-5-yl)ethanone derivatives into organic field-effect transistors to improve charge carrier mobility.
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