6-bromo-4-chloro-2-chloromethyl-quinazoline
$500.00
CAS No.: 1216816-26-0
Catalog No.: 197584
Purity: 95%
MF: C9H5BrCl2N2
MW: 291.963
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NC(=NC2=CC1)CCl)Cl
Catalog No.: 197584
Purity: 95%
MF: C9H5BrCl2N2
MW: 291.963
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NC(=NC2=CC1)CCl)Cl
6-bromo-4-chloro-2-chloromethyl-quinazoline; CAS No.: 1216816-26-0; 6-bromo-4-chloro-2-chloromethyl-quinazoline. PROPERTIES: This bromo-chloro-chloromethyl-substituted quinazoline features molecular formula C?H?BrCl?N? with molecular weight 282.02 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 90-95 C. Exhibits IR absorption for C-Br (~600-500 cm??) and C-Cl groups (~600-500 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a bromo-chloro-chloromethyl-substituted quinazoline, 6-bromo-4-chloro-2-chloromethyl-quinazoline is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the bromo and chloro substituents provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its chloromethyl group enables conjugation to biomolecules via alkylation reactions (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the bromo and chloro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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