4-chloro-7-(trifluoromethyl)quinazoline
$250.00
CAS No.: 16499-65-3
Catalog No.: 196013
Purity: 95%
MF: C9H4ClF3N2
MW: 232.592
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC2=CC(=CC=C12)C(F)(F)F
Catalog No.: 196013
Purity: 95%
MF: C9H4ClF3N2
MW: 232.592
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC2=CC(=CC=C12)C(F)(F)F
4-chloro-7-(trifluoromethyl)quinazoline; CAS No.: 16499-65-3; 4-chloro-7-(trifluoromethyl)quinazoline. PROPERTIES: 4-chloro-7-(trifluoromethyl)quinazoline appears as a white to slightly yellow crystalline solid with molecular formula C9H4ClF3N2, possessing a molar mass of approximately 237.6 g/mol. It exhibits low water solubility but dissolves well in organic solvents like dichloromethane and acetone. Thermal analysis indicates melting point in the range of 92-96 C. Storage requirements include maintaining in well-sealed containers at room temperature, protected from moisture and strong oxidizing agents. Safety considerations identify it as harmful if swallowed and causing skin irritation. Proper handling demands use of protective equipment and implementation of engineering controls to minimize dust generation. APPLICATIONS: This compound is extensively utilized in pharmaceutical synthesis as a precursor to kinase inhibitors, particularly for developing anticancer therapies targeting BTK and FLT3 enzymes. Its trifluoromethyl group at position 7 enhances metabolic stability and binding affinity in bioactive molecules. In medicinal chemistry research, it serves as a starting material for synthesizing dual kinase/HDAC inhibitors. The compound also contributes to agricultural chemical development (non-application context) through safener compound research, with applications detailed in Journal of Medicinal Chemistry publications and pharmaceutical patent filings, demonstrating its significant role in therapeutic agent innovation across multiple disease targets.
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