4-chloro-7-iodo-2-(trifluoromethyl)quinazoline
$600.00
CAS No.: 959237-77-5
Catalog No.: 197598
Purity: 95%
MF: C9H3ClF3IN2
MW: 358.488
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC2=CC(=CC=C12)I)C(F)(F)F
Catalog No.: 197598
Purity: 95%
MF: C9H3ClF3IN2
MW: 358.488
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC2=CC(=CC=C12)I)C(F)(F)F
4-chloro-7-iodo-2-(trifluoromethyl)quinazoline; CAS No.: 959237-77-5; 4-chloro-7-iodo-2-(trifluoromethyl)quinazoline. PROPERTIES: This chloro-iodo-trifluoromethyl-substituted quinazoline features molecular formula C?H?ClF?N?O with molecular weight 308.54 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 120-125 C. Exhibits IR absorption for C-Cl (~600-500 cm??), C-I (~550-450 cm??), and C-F groups (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a chloro-iodo-trifluoromethyl-substituted quinazoline, 4-chloro-7-iodo-2-(trifluoromethyl)quinazoline is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the chloro, iodo, and trifluoromethyl groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its trifluoromethyl group enhances solubility and binding affinity for target biomolecules (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the trifluoromethyl group contributes to improved flame retardancy and mechanical properties (Polymer International).
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