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tert-butyl (4aR,7aS)-octahydropyrrolo[3,4-b]morpholine-6-carboxylate
$665.00
CAS No.: 159991-18-1
Catalog No.: 195533
Purity: 95%
MF: C11H20N2O3
MW: 228.292
Storage: 2-8 degree Celsius
SMILES: O=C(N(C1)C[C@@]2([H])[C@]1([H])NCCO2)OC(C)(C)C
Catalog No.: 195533
Purity: 95%
MF: C11H20N2O3
MW: 228.292
Storage: 2-8 degree Celsius
SMILES: O=C(N(C1)C[C@@]2([H])[C@]1([H])NCCO2)OC(C)(C)C
tert-butyl (4aR,7aS)-octahydropyrrolo[3,4-b]morpholine-6-carboxylate; CAS No.: 159991-18-1; tert-butyl (4aR,7aS)-octahydropyrrolo[3,4-b]morpholine-6-carboxylate. PROPERTIES: tert-butyl (4aR,7aS)-octahydropyrrolo[3,4-b]morpholine-6-carboxylate is a colorless to pale yellow oil with molecular formula C12H23NO3. It exhibits a boiling point around 180-190 C at 10 mmHg and shows moderate solubility in ethyl acetate and methylene chloride. The compound should be stored at 0-5 C in tightly sealed containers under nitrogen atmosphere to prevent oxidation. Safety measures require avoiding exposure to open flames due to its flammability and using chemical splash goggles to prevent eye contact. APPLICATIONS: This chiral heterocyclic compound serves as a valuable intermediate in the synthesis of centrally acting nervous system agents, where the tert-butyl (4aR,7aS)-octahydropyrrolo[3,4-b]morpholine-6-carboxylate configuration facilitates blood-brain barrier penetration (Journal of Medicinal Chemistry). In asymmetric catalysis, the compound acts as a chiral auxiliary for inducing stereocontrol in C-C bond forming reactions (Journal of the American Chemical Society). Additionally, its protected amine functionality makes it suitable for peptide synthesis applications where temporary protection is required during solid-phase synthesis (Bioconjugate Chemistry).
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