tert-Butyl (1-(pyrrolidin-3-yl)cyclopropyl)carbamate
$300.00
CAS No.: 185693-07-6
Catalog No.: 195724
Purity: 95%
MF: C12H22N2O2
MW: 226.32
Storage: 2-8 degree Celsius
SMILES: N1CC(CC1)C1(CC1)NC(OC(C)(C)C)=O
Catalog No.: 195724
Purity: 95%
MF: C12H22N2O2
MW: 226.32
Storage: 2-8 degree Celsius
SMILES: N1CC(CC1)C1(CC1)NC(OC(C)(C)C)=O
tert-Butyl (1-(pyrrolidin-3-yl)cyclopropyl)carbamate; CAS No.: 185693-07-6; tert-Butyl (1-(pyrrolidin-3-yl)cyclopropyl)carbamate. PROPERTIES: tert-Butyl (1-(pyrrolidin-3-yl)cyclopropyl)carbamate has molecular formula C13H23N2O2, corresponding to a molecular weight of 243.33 g/mol. It appears as a white crystalline powder with a melting point between 75-78 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 2.3 and exhibits moderate aqueous solubility. APPLICATIONS: This tert-butyl (1-(pyrrolidin-3-yl)cyclopropyl)carbamate is extensively used in the synthesis of antimicrobial agents. Its pyrrolidine-cyclopropyl-carbamate structure provides a novel scaffold for developing antibacterial agents targeting bacterial DNA gyrase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against Gram-negative pathogens. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The cyclopropyl group provides steric effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent dyes. The carbamate group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Dyes and Pigments.
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