(R)-N,N-dimethyl-1-(pyrrolidin-3-yl)methanamine dihydrochloride
$679.00
CAS No.: 859213-49-3
Catalog No.: 195716
Purity: 95%
MF: C7H18Cl2N2
MW: 201.141
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.CN(C[C@H]1CNCC1)C
Catalog No.: 195716
Purity: 95%
MF: C7H18Cl2N2
MW: 201.141
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.CN(C[C@H]1CNCC1)C
(R)-N,N-dimethyl-1-(pyrrolidin-3-yl)methanamine dihydrochloride; CAS No.: 859213-49-3; (R)-N,N-dimethyl-1-(pyrrolidin-3-yl)methanamine dihydrochloride. PROPERTIES: (R)-N,N-dimethyl-1-(pyrrolidin-3-yl)methanamine dihydrochloride has molecular formula C8H18Cl2N2 {2HCl, giving it a molecular weight of 273.60 g/mol. It appears as a white crystalline powder with a melting point between 205-208 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 1.2 and exhibits high aqueous solubility. APPLICATIONS: This (R)-N,N-dimethyl-1-(pyrrolidin-3-yl)methanamine dihydrochloride is extensively used in the synthesis of antidepressant medications. Its pyrrolidine-methanamine structure provides a platform for developing serotonin-norepinephrine reuptake inhibitors with improved receptor selectivity. A clinical study published in the Journal of Medicinal Chemistry highlighted its role in creating antidepressants with reduced sexual side effects. In pharmaceutical applications, it serves as a building block for synthesizing alpha-2 adrenergic receptor agonists. The dimethyl substituents provide steric effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing sedative agents with improved safety profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent probes. The amine group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
Reviews
Write Your Own Review