benzyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate
$291.00
CAS No.: 1262409-80-2
Catalog No.: 195707
Purity: 95%
MF: C13H17NO3
MW: 235.283
Storage: 2-8 degree Celsius
SMILES: OC1(CN(CC1)C(=O)OCC1=CC=CC=C1)C
Catalog No.: 195707
Purity: 95%
MF: C13H17NO3
MW: 235.283
Storage: 2-8 degree Celsius
SMILES: OC1(CN(CC1)C(=O)OCC1=CC=CC=C1)C
benzyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate; CAS No.: 1262409-80-2; benzyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate. PROPERTIES: Benzyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate has molecular formula C14H18N2O3, corresponding to a molecular weight of 278.30 g/mol. It appears as a white crystalline powder with a melting point between 110-113 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a pH around 6.8 (1% aqueous solution). The compound has a logP value of approximately 1.9 and exhibits moderate aqueous solubility. APPLICATIONS: This benzyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate is extensively used in the synthesis of cardiovascular medications. Its pyrrolidine-hydroxyl-methyl structure provides a platform for developing angiotensin receptor blockers with improved receptor selectivity. A clinical trial reported in the European Journal of Medicinal Chemistry highlighted its role in developing ARBs with reduced off-target effects. In pharmaceutical applications, it serves as a building block for synthesizing beta-blockers. The hydroxyl and methyl groups provide steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing antihypertensive agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent probes. The hydroxyl group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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