1-(pyrimidin-2-yl)pyrrolidin-3-amine dihydrochloride
$389.00
CAS No.: 2098048-53-2
Catalog No.: 195708
Purity: 95%
MF: C8H14Cl2N4
MW: 237.134
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.N1=C(N=CC=C1)N1CC(CC1)N
Catalog No.: 195708
Purity: 95%
MF: C8H14Cl2N4
MW: 237.134
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.N1=C(N=CC=C1)N1CC(CC1)N
1-(pyrimidin-2-yl)pyrrolidin-3-amine dihydrochloride; CAS No.: 2098048-53-2; 1-(pyrimidin-2-yl)pyrrolidin-3-amine dihydrochloride. PROPERTIES: 1-(pyrimidin-2-yl)pyrrolidin-3-amine dihydrochloride has molecular formula C8H12N4 {2HCl, giving it a molecular weight of 248.12 g/mol. It appears as a white crystalline powder with a melting point between 215-218 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 0.9 and exhibits high aqueous solubility. APPLICATIONS: This 1-(pyrimidin-2-yl)pyrrolidin-3-amine dihydrochloride is extensively used in the synthesis of antimicrobial agents. Its pyrrolidine-pyrimidine-amine structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The pyrimidine group provides hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of pyrimidine-containing fluorescent dyes. The amine group provides a site for installing fluorescence tags, enabling detection of nucleic acid hybridization events, as reported in Chemical Communications.
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