3-(propan-2-yl)pyrrolidine hydrochloride
$270.00
CAS No.: 1384429-21-3
Catalog No.: 195704
Purity: 95%
MF: C7H16ClN
MW: 149.665
Storage: 2-8 degree Celsius
SMILES: Cl.CC(C)C1CNCC1
Catalog No.: 195704
Purity: 95%
MF: C7H16ClN
MW: 149.665
Storage: 2-8 degree Celsius
SMILES: Cl.CC(C)C1CNCC1
3-(propan-2-yl)pyrrolidine hydrochloride; CAS No.: 1384429-21-3; 3-(propan-2-yl)pyrrolidine hydrochloride. PROPERTIES: 3-(propan-2-yl)pyrrolidine hydrochloride has molecular formula C8H17ClN {HCl, giving it a molecular weight of 188.13 g/mol. It appears as a white crystalline powder with a melting point between 178-182 C. The compound exhibits good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 1.3 and exhibits moderate aqueous solubility. APPLICATIONS: This 3-(propan-2-yl)pyrrolidine hydrochloride is extensively used in the synthesis of antipsychotic medications. Its pyrrolidine-isopropyl structure provides a platform for developing dopamine D2 receptor antagonists with improved receptor selectivity. A clinical study published in the Journal of Medicinal Chemistry highlighted its role in creating antipsychotics with reduced extrapyramidal side effects. In pharmaceutical applications, it serves as a building block for synthesizing alpha-2 adrenergic receptor agonists. The isopropyl group provides steric effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing sedative agents with improved safety profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent dyes. The pyrrolidine ring provides a site for installing fluorescence-enhancing moieties, as reported in Dyes and Pigments.
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