(2R,4R)-tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate
$225.00
CAS No.: 848488-71-1
Catalog No.: 193041
Purity: 95%
MF: C10H18N2O4
MW: 230.264
Storage: -20 degree Celsius
SMILES: C(N)(=O)[C@@H]1N(C[C@@H](C1)O)C(=O)OC(C)(C)C
Catalog No.: 193041
Purity: 95%
MF: C10H18N2O4
MW: 230.264
Storage: -20 degree Celsius
SMILES: C(N)(=O)[C@@H]1N(C[C@@H](C1)O)C(=O)OC(C)(C)C
(2R,4R)-tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate; CAS No.: 848488-71-1; (2R,4R)-tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate. PROPERTIES: This compound appears as a white to off-white crystalline solid with molecular formula C11H18N2O4 and a molecular weight of 238.28 g/mol. It exhibits a melting point in the range of 152-156 C and demonstrates moderate solubility in common organic solvents like methanol and ethyl acetate. The substance is sensitive to hydrolysis and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at temperatures below 25 C, protected from moisture and light. When handling, standard laboratory safety protocols should be followed, including the use of protective gloves and eye wear, as (2R,4R)-tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate may cause skin irritation. The hydroxyl group requires careful handling in strongly acidic environments. APPLICATIONS: In the pharmaceutical industry, (2R,4R)-tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate serves as an intermediate for synthesizing non-steroidal anti-inflammatory drugs (NSAIDs), as described in medicinal chemistry literature focusing on pyrrolidine derivatives. Its hydroxyl substituent enables formation of bioactive esters through esterification reactions. Additionally, this compound functions as a building block for preparing agrochemicals with fungicidal activities through coupling reactions. Academic research has explored its potential in metal coordination chemistry for creating luminescent sensors, as reported in inorganic chemistry journals. The pyrrolidine ring system also facilitates formation of metal-organic frameworks (MOFs), making it valuable for gas storage applications in materials science, as evidenced by studies in crystallography publications.
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