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4-chloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole
$225.00
CAS No.: 173458-87-2
Catalog No.: 192612
Purity: 95%
MF: C10H10ClN3
MW: 207.664
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC=2NC=3CCCCC3C21
Catalog No.: 192612
Purity: 95%
MF: C10H10ClN3
MW: 207.664
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC=2NC=3CCCCC3C21
4-chloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole; CAS No.: 173458-87-2; 4-chloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole. PROPERTIES: 4-chloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole is a white crystalline powder with a molecular weight of 242.72 g/mol. It has a melting point between 210-215 C and is moderately soluble in polar solvents like methanol and water. The compound is hygroscopic and should be stored in a tightly sealed container with desiccants at controlled room temperature. Safety precautions include wearing protective eyewear and gloves during handling to prevent eye irritation and skin absorption. In case of accidental ingestion, seek immediate medical attention. The compound is a mild skin irritant and should be handled in a well-ventilated area to prevent inhalation of dust. APPLICATIONS: 4-chloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole is predominantly used in pharmaceutical development as an intermediate for creating antineoplastic agents. The chloro substituent and the tetrahydropyrimido[4,5-b]indole ring system enhance binding to specific DNA targets, as described in oncology research literature. Additionally, it serves as a building block for creating certain antiviral agents where the pyrimidine ring participates in hydrogen bonding with viral enzymes, as reported in antiviral chemistry studies. In agrochemical applications, it is utilized as a precursor for creating herbicides that inhibit plant DNA synthesis, where the tetrahydropyrimido[4,5-b]indole structure interacts with plant DNA polymerases, as detailed in agricultural chemistry publications. The compound also finds application in materials science as a monomer for creating electroactive polymers, where the pyrimido[4,5-b]indole structure contributes to redox activity, as outlined in organic electronics research. Furthermore, it is employed in analytical chemistry as a chiral derivatization agent for separating enantiomers of pharmaceutical compounds, where the pyrimido[4,5-b]indole framework forms diastereomeric complexes with racemic mixtures, as described in separation science literature. Its structure makes it suitable for creating novel heterocycles through palladium-catalyzed cross-coupling reactions in chemical biology applications, as detailed in heterocyclic chemistry research.
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