methyl 4-(trifluoromethyl)pyrimidine-5-carboxylate
$225.00
CAS No.: 1803738-77-3
Catalog No.: 192961
Purity: 95%
MF: C7H5F3N2O2
MW: 206.123
Storage: 2-8 degree Celsius
SMILES: FC(C1=NC=NC=C1C(=O)OC)(F)F
Catalog No.: 192961
Purity: 95%
MF: C7H5F3N2O2
MW: 206.123
Storage: 2-8 degree Celsius
SMILES: FC(C1=NC=NC=C1C(=O)OC)(F)F
methyl 4-(trifluoromethyl)pyrimidine-5-carboxylate; CAS No.: 1803738-77-3; methyl 4-(trifluoromethyl)pyrimidine-5-carboxylate. PROPERTIES: This compound appears as a white crystalline solid with molecular formula C7H5F3N2O2 and a molecular weight of 214.12 g/mol. It demonstrates a melting point in the range of 92-96 C and shows moderate solubility in common organic solvents like methanol and ethyl acetate. The substance is sensitive to hydrolysis and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at temperatures below 25 C, protected from moisture and light. When handling, standard laboratory safety protocols should be followed, including the use of protective gloves and eye wear, as methyl 4-(trifluoromethyl)pyrimidine-5-carboxylate may cause skin irritation. The ester group requires careful handling in strongly basic environments. APPLICATIONS: In the pharmaceutical industry, methyl 4-(trifluoromethyl)pyrimidine-5-carboxylate serves as an intermediate for synthesizing non-steroidal anti-inflammatory drugs (NSAIDs), as described in medicinal chemistry literature focusing on pyrimidine derivatives. Its trifluoromethyl substituent enables improved metabolic stability in biological systems. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through coupling reactions. Academic research has explored its utility in the development of fluorescent probes for bioimaging applications, as reported in biochemical journals. The pyrimidine ring system also facilitates coordination with metal ions, making it valuable for creating luminescent materials in materials science applications, as evidenced by inorganic chemistry publications.
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