5-bromo-6-(trifluoromethyl)pyrimidin-4(3H)-one
$200.00
CAS No.: 126538-81-6
Catalog No.: 192959
Purity: 95%
MF: C5H2BrF3N2O
MW: 242.982
Storage: 2-8 degree Celsius
SMILES: BrC=1C(NC=NC1C(F)(F)F)=O
Catalog No.: 192959
Purity: 95%
MF: C5H2BrF3N2O
MW: 242.982
Storage: 2-8 degree Celsius
SMILES: BrC=1C(NC=NC1C(F)(F)F)=O
5-bromo-6-(trifluoromethyl)pyrimidin-4(3H)-one; CAS No.: 126538-81-6; 5-bromo-6-(trifluoromethyl)pyrimidin-4(3H)-one. PROPERTIES: This compound appears as a white crystalline powder with molecular formula C5H3BrF3N2O and a molecular weight of 238.00 g/mol. It demonstrates a melting point in the range of 188-192 C and shows moderate solubility in common organic solvents like dimethylformamide and dimethyl sulfoxide. The substance is hygroscopic and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at room temperature with protection from moisture and light. When handling, standard laboratory safety precautions should be observed, including the use of gloves and eye protection, as 5-bromo-6-(trifluoromethyl)pyrimidin-4(3H)-one may release irritating vapors upon heating. The bromo group requires careful handling in strongly basic environments. APPLICATIONS: In the pharmaceutical industry, 5-bromo-6-(trifluoromethyl)pyrimidin-4(3H)-one serves as an intermediate for synthesizing anticancer agents, as described in medicinal chemistry literature focusing on kinase inhibitors. Its bromo substituent enables participation in cross-coupling reactions for constructing biaryl systems. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through nucleophilic aromatic substitution reactions. Academic research has explored its potential in the development of fluorescent probes for bioimaging applications, as reported in biochemical journals. The pyrimidinone ring system also facilitates coordination with metal ions, making it valuable for creating luminescent materials in materials science applications, as evidenced by inorganic chemistry publications.
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