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tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate
$300.00
CAS No.: 2007920-62-7
Catalog No.: 192079
Purity: 95%
MF: C11H13BrN4O2
MW: 313.155
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)NC(OC(C)(C)C)=O
Catalog No.: 192079
Purity: 95%
MF: C11H13BrN4O2
MW: 313.155
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)NC(OC(C)(C)C)=O
tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate; CAS No.: 2007920-62-7; tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate. PROPERTIES: tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate is a white crystalline powder with molecular formula C12H13BrN5O2. It has a molar mass of 356.17 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 165-168 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety measures include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong acids. APPLICATIONS: In pharmaceutical development, tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate serves as a building block for creating kinase inhibitors. Research groups focusing on cancer therapy have utilized this compound to develop inhibitors targeting the Aurora kinase family. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the kinase active site. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate exhibited anxiolytic effects in rodent models of anxiety. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic photovoltaics. Researchers at a renewable energy laboratory incorporated tert-butyl 3-bromopyrazolo[1,5-a]pyrimidin-6-ylcarbamate derivatives into donor-acceptor architectures to improve power conversion efficiencies in small-molecule solar cells.
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