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3-bromopyrazolo[1,5-a]pyrimidin-6-amine
$450.00
CAS No.: 1367955-95-0
Catalog No.: 192080
Purity: 95%
MF: C6H5BrN4
MW: 213.038
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)N
Catalog No.: 192080
Purity: 95%
MF: C6H5BrN4
MW: 213.038
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)N
3-bromopyrazolo[1,5-a]pyrimidin-6-amine; CAS No.: 1367955-95-0; 3-bromopyrazolo[1,5-a]pyrimidin-6-amine. PROPERTIES: 3-bromopyrazolo[1,5-a]pyrimidin-6-amine is a pale yellow crystalline solid with molecular formula C8H6BrN5. It has a molar mass of 261.07 g/mol and exhibits limited water solubility but good solubility in methanol and DMSO. The compound melts between 190-193 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical research, 3-bromopyrazolo[1,5-a]pyrimidin-6-amine serves as a key intermediate for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create inhibitors targeting the Janus kinase (JAK) family in inflammatory diseases. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the kinase active site. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate AMPA receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 3-bromopyrazolo[1,5-a]pyrimidin-6-amine exhibited cognitive-enhancing effects in rodent models of memory impairment. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 3-bromopyrazolo[1,5-a]pyrimidin-6-amine derivatives into organic field-effect transistors to improve charge carrier mobility.
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