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methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate
$300.00
CAS No.: 1823420-32-1
Catalog No.: 192058
Purity: 95%
MF: C8H6BrN3O2
MW: 256.059
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)C(=O)OC
Catalog No.: 192058
Purity: 95%
MF: C8H6BrN3O2
MW: 256.059
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)C(=O)OC
methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate; CAS No.: 1823420-32-1; methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate. PROPERTIES: Methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate is a pale yellow crystalline powder with molecular formula C10H7BrN4O2. It has a molar mass of 295.08 g/mol and exhibits limited water solubility but good solubility in methanol and ethyl acetate. The compound melts between 145-148 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety measures include using chemical-resistant gloves and safety goggles. The compound may cause eye irritation, so immediate rinsing with water is required upon contact. If inhaled, moving to fresh air and providing oxygen if needed is advised. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In pharmaceutical development, methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate serves as a building block for creating kinase inhibitors. Research groups focusing on cancer therapy have utilized this compound to develop inhibitors targeting the Aurora kinase family. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the kinase active site. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate AMPA receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate exhibited cognitive-enhancing effects in rodent models of memory impairment. Additionally, in materials science, the compound's electron-withdrawing bromine group makes it suitable for use in electron-transporting layers of organic light-emitting diodes (OLEDs). Researchers at a display technology company incorporated methyl 3-bromopyrazolo[1,5-a]pyrimidine-6-carboxylate derivatives into OLED devices to improve electron injection efficiencies.
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