methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride
$225.00
CAS No.: 362707-24-2
Catalog No.: 192854
Purity: 95%
MF: C8H16ClNO3
MW: 209.673
Storage: 2-8 degree Celsius
SMILES: Cl.NCC1(CCOCC1)C(=O)OC
Catalog No.: 192854
Purity: 95%
MF: C8H16ClNO3
MW: 209.673
Storage: 2-8 degree Celsius
SMILES: Cl.NCC1(CCOCC1)C(=O)OC
methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride; CAS No.: 362707-24-2; methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride. PROPERTIES: This aminomethyl-substituted tetrahydropyran carboxylate salt has molecular formula C9H16N2O2 {HCl. It appears as a white crystalline powder. The methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 180-185 C (with decomposition), and it has a molecular weight of approximately 204.70 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The methyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate hydrochloride functions as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the tetrahydropyran ring provides essential hydrogen bonding interactions with receptor subtypes (as reported in medicinal chemistry literature). The aminomethyl group forms additional hydrogen bonds with receptor residues. Additionally, the compound serves as a building block in the preparation of bioconjugates for drug delivery systems where the carboxylic acid group reacts with amino groups on targeting moieties, as described in pharmaceutical sciences journals. The carboxylic acid can be further functionalized through esterification or amidation reactions to produce various derivatives for chemical research applications.
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