N-Isobutyrylguanosine
$350.00
CAS No.: 64350-24-9
Catalog No.: 198000
Purity: 95%
MF: C14H19N5O6
MW: 353.335
Storage: 2-8 degree Celsius
SMILES: C(C(C)C)(=O)NC=1NC(C=2N=CN([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C2N1)=O
Catalog No.: 198000
Purity: 95%
MF: C14H19N5O6
MW: 353.335
Storage: 2-8 degree Celsius
SMILES: C(C(C)C)(=O)NC=1NC(C=2N=CN([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C2N1)=O
CAS No.: 64350-24-9; N-Isobutyrylguanosine. PROPERTIES: N-Isobutyrylguanosine is a nucleoside derivative with molecular formula C12H18N5O6P and molecular weight 397.28 g/mol. It typically appears as a white crystalline powder with good water solubility. The compound is hygroscopic and sensitive to acidic conditions, requiring storage at -20 C in a tightly sealed container with desiccant. Safety precautions include avoiding inhalation of dust and using protective equipment to prevent skin contact, as it may cause mild irritation. APPLICATIONS: In molecular biology, N-Isobutyrylguanosine is used as a modified nucleotide for RNA labeling and detection. The isobutyryl group provides a handle for further chemical modification or detection via antibodies specific to acyl modifications. In RNA structure studies, it serves as a probe for investigating nucleic acid hybridization and conformational changes. Additionally, the compound is utilized in developing RNA-based therapeutics where chemical modifications enhance stability against nucleases and improve binding affinity to target sequences. In diagnostic applications, it enables visualization of RNA species in cells or tissues through incorporation into RNA probes followed by detection using appropriate antibodies or chemical reagents. The modified guanosine can also be incorporated into aptamers to enhance their binding properties for biosensing applications. (Molecular biology protocols and nucleic acid chemistry literature)
Reviews
Write Your Own Review