N-(6-hydroxy-7H-purin-2-yl)acetamide
$400.00
CAS No.: 19962-37-9
Catalog No.: 196327
Purity: 95%
MF: C7H7N5O2
MW: 193.166
Storage: 2-8 degree Celsius
SMILES: OC1=C2NC=NC2=NC(=N1)NC(C)=O
Catalog No.: 196327
Purity: 95%
MF: C7H7N5O2
MW: 193.166
Storage: 2-8 degree Celsius
SMILES: OC1=C2NC=NC2=NC(=N1)NC(C)=O
N-(6-hydroxy-7H-purin-2-yl)acetamide; CAS No.: 19962-37-9; N-(6-hydroxy-7H-purin-2-yl)acetamide. PROPERTIES: This compound presents an N-(6-hydroxy-7H-purin-2-yl)acetamide structure, combining a hydroxypurine group and an acetamide substituent. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 180.1 g/mol (C6H7N4O2). The melting point ranges between 160-165 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: N-(6-Hydroxy-7H-purin-2-yl)acetamide serves as a specialized intermediate in pharmaceutical research. Its N-(6-hydroxy-7H-purin-2-yl)acetamide structure enables diverse reactivity patterns, including nucleophilic substitution at the hydroxypurine group and amide bond formation. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and nucleic acid-binding proteins. The hydroxypurine group provides hydrogen-bonding capabilities for improved target binding. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the N-(6-hydroxy-7H-purin-2-yl)acetamide scaffold for improved biological activity and pharmacokinetic properties.
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