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1-tert-Butyl 3-ethyl 5-hydroxypiperidine-1,3-dicarboxylate
$300.00
CAS No.: 1272756-00-9
Catalog No.: 195619
Purity: 95%
MF: C13H23NO5
MW: 273.329
Storage: 2-8 degree Celsius
SMILES: OC1CC(CN(C1)C(=O)OC(C)(C)C)C(=O)OCC
Catalog No.: 195619
Purity: 95%
MF: C13H23NO5
MW: 273.329
Storage: 2-8 degree Celsius
SMILES: OC1CC(CN(C1)C(=O)OC(C)(C)C)C(=O)OCC
1-tert-Butyl 3-ethyl 5-hydroxypiperidine-1,3-dicarboxylate; CAS No.: 1272756-00-9; 1-tert-Butyl 3-ethyl 5-hydroxypiperidine-1,3-dicarboxylate. PROPERTIES: 1-tert-Butyl 3-ethyl 5-hydroxypiperidine-1,3-dicarboxylate is a piperidine derivative with a molecular weight of approximately 269.3 g/mol. This compound typically exists as a colorless to pale yellow oil with moderate viscosity and demonstrates good solubility in common organic solvents. It is sensitive to both moisture and temperature fluctuations, necessitating storage in a tightly sealed container at temperatures between 0-5 C. Special handling precautions include avoiding exposure to strong acids and bases, as the hydroxyl group may undergo esterification or etherification reactions. The compound presents moderate acute toxicity via inhalation routes. APPLICATIONS: 1-tert-Butyl 3-ethyl 5-hydroxypiperidine-1,3-dicarboxylate serves as a protected piperidine building block in medicinal chemistry. The hydroxyl group provides a versatile handle for further functionalization, including glycosylation and phosphate ester formation. In pharmaceutical synthesis, this compound has been employed in the preparation of P2X receptor antagonists where the piperidine ring contributes to receptor binding (source: Journal of Medicinal Chemistry). Additionally, its application extends to the synthesis of antiviral agents, where the hydroxyl group participates in hydrogen bonding interactions with viral enzymes (source: Antiviral Research). The compound's ability to undergo selective protection and deprotection strategies enhances its utility in complex molecule synthesis (source: Organic Process Research & Development).
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